高 瑜高 瑜
职称：副教授
硕士生导师（药剂学专业）
电话：0591-87509185
Email: hellogaoyu@126.com
教育背景
☆ 2005.09–2010.07 中国科学院上海药物研究所 博士
专业：药剂学
☆ 2001.09–2005.07 福州大学 学士
专业：制药工程
工作经历
☆ 2010.07–2011.10 中国科学院上海药物研究所 助理研究员
☆ 2013.03–至今 福州大学 副教授
☆ 2014.05–至今 福州大学化学学院 化学生物与制药系秘书
教学方向
研究生课程：《现代药剂学》、《新药研发的跨学科知识和技能》
本科生课程：《综合化学实验》、《仪器分析实验》、《制药工程导论》
助教课程：《无机和分析化学》、《仪器分析》
科研经验
主要从事创新药物制剂的研究，以提高药物的有效性、降低毒副作用。主要学术成绩涵盖药物新材料、新技术和新工艺的应用基础研究：（1）成功构建多种新型靶向纳米载药系统改善难溶性药物的功效，降低毒副作用；（2）设计并合成出一系列新型基因非病毒载体显著提高基因药物转染效率；（3）构建多种纳米载药系统用于改善临床肿瘤治疗效果并进行详细机制研究；（4）设计构建可特异性调控循环肿瘤细胞用于预防肿瘤转移的纳米药物。以上学术成就已在国际重要学术期刊Biotechnol Adv、Drug Discov Today、ACS Nano、Biomaterials、J Controlled Release、Mol Pharmaceutics等上发表论文40余篇，累计影响因子达276分，第一作者22篇，累计影响因子达130分，论文已被引用950余次，其中影响因子5.0以上的论文29篇，有18篇论文刊登在《SCI-JCR期刊综合评价主题分区表》一区期刊。相关成果申请专利14件，已授权6件。主持国家自然科学基金青年项目1项，以学术骨干参与两项国家重大科学研究计划项目，参与多项国家自然科学基金面上项目、“973”项目及国家重大新药创制项目等；获得上海市药学科技一等奖（2013，排名第五）、上海市药学科技一等奖（2009，排名第三）、中科院百篇优秀博士论文（2011）、中科院院长奖优秀奖（2010）等奖项。（截止至2015.8.1）
主持（参与）的项目
1、 还原响应性聚（β-氨基酯）衍生物共输送不同RNA 药物降低肿瘤耐药性研究（81102388），国家基金委青年科学基金项目，2012.01-2014.12，项目负责人
2、 新型还原响应性阳离子聚合物共输送不同shRNA药物降低肿瘤耐药性研究，中国科学院“优秀博士学位论文、院长奖获得者科研启动专项资金”，2012.01-2013.12，项目负责人
3、 靶向循环肿瘤细胞纳米载体的构建及抗粘附作用研究（2013-XQ-8），福州大学科技发展基金，2013.06-2015.08，项目负责人
4、 多功能介孔二氧化硅纳米载体的构建及其抗肿瘤转移研究（2014-XY-7），福州大学科技发展基金，2014.06-2017.08，项目负责人
5、 靶向循环肿瘤细胞纳米载体的构建及抗肿瘤转移研究（XRC-1323），福州大学人才基金，2013.06-2015.05，项目负责人
6、 基于PAMAM树状大分子的肿瘤靶向纳米药物的构建和体外抗肿瘤作用的研究（J1103303，2013-026），国家基础科学人才培养基金项目，2013.6-2015.5，子课题指导
7、 肝癌治疗的新型纳米药物研究 （2012CB932500），国家重大科学研究计划项目，2012.1-2016.8，学术骨干
8、 肺癌在体分子分型的新型纳米分子成像探针基础研究（2015CB931800），国家重大科学研究计划项目，2015.1-2019.8，学术骨干
9、 适体分子与核酸探针在肿瘤转移预防和预警研究中的应用（XRC-1432），福州大学人才基金，2014.1-2016.12，参与，排名第二
10、 预防肿瘤手术后再转移的源头新药——美她司酮的注册研究（HX2014-25），福建省发展和改革委员会，2014.1-2017.12，参与，排名第五
11、 阳离子Click聚合物/DNA自组装纳米粒的研究 （30873169），国家基金委面上项目 2009.01-2011.12，主要完成人
12、 基于阳离子Click聚合物的基因纳米载体研究 （0852nm05700），上海市科委 2008.10-2010.09，主要完成人
13、 基于纳米技术的药物新剂型改善肿瘤治疗效果的应用基础研究 （2010CB934000），国家科技部重大科学研究计划 2010.01-2014.08，参与
发表论文
1. Yu Gao, Ye Ding, Haiying Chen, Haijun
Chen* and Jia Zhou*. Targeting krüppel-like factor 5 (KLF5) for cancer therapy.Current
Topics in Medicinal Chemistry. 15 (2015) 699-713 (IF = 3.402)
2. Yu Gao*, Zhihong Li, Chaoqun Wang, Jiali
You, Biyu Jin, Fan Mo, Jianzhong Chen, Yunquan Zheng, Haijun Chen*. Self-assembled
chitosan/rose bengal derivative nanoparticles for targeted sonodynamic therapy:
preparation and tumor accumulation. RSC Advances, 5 (2015) 17915 - 17923
(IF = 3.840)
3. Yu Gao*, Zhihong Li, Xiaodong Xie,
Chaoqun Wang, Jiali You, Fan Mo, Biyu Jin, Jianzhong Chen, Jingwei Shao, Haijun
Chen, Lee Jia*. Dendrimeric anticancer prodrugs for targeted delivery of
ursolic acid to folate receptor-expressing cancer cells: synthesis and
biological evaluation. Eur. J. Pharm. Sci. 70 (2015) 55-63 (IF = 3.350)
4. Haijun
Chen#, Yu Gao# (co-first author), Ailan Wang, Xiaobin
Zhou, Yunquan Zheng, Jia Zhou*. Evolution in Medicinal Chemistry of Ursolic
Acid Derivatives as Anticancer Agents. Eur. J. Med. Chem. 92 (2015) 648-655
(IF = 3.447)
5. Jingjing
Xie, Yu Gao, Rongli Zhao, Patrick
J. Sinko, Songen Gu, Jichuang Wang, Yuanfang Li, Yusheng Lu, Suhong Yu, Lie
Wang, Shuming Chen, Jingwei Shao, Lee Jia. Ex vivo and in vivo capture and
deactivation of circulating tumor cells by dual-antibody-coated nanomaterials. Journal of Controlled Release 209 (2015)159-169.(IF = 7.705)
6. Jingjing
Xie, Yusheng Lu, Haiyan Dong, Rongli Zhao, Hongning Chen, Weiyu Shen, Patrick
J. Sinko, Yewei Zhu, Jichuang Wang, Jingwei Shao*, Yu Gao, Fangwei Xie, and Lee Jia*. Enhanced Specificity in
Capturing and Restraining Circulating Tumor Cells with Dual Antibody–Dendrimer Conjugates.Adv.
Funct. Mater. 25 (2015) 1304–1313. (IF = 11.805)
7. Suhong
Yu, Xingtian Yang, Yewei Zhu, Fangwei Xie, Yusheng Lu, Ting Yu, Cuicui Yan,
Jingwei Shao, Yu Gao, Fan Mo,
Guoneng Cai, Patrick J. Sinko, Lee Jia*. Systems pharmacology of mifepristone (RU486)
reveals its 47 hub targets and network: Comprehensive analysis and pharmacological
focus on FAK-Src-Paxillin complex. Sci. Rep. 5 (2015) 7830. (IF = 5.578)
8. Haiyan
Dong, Xiang Yang, Jingjing Xie, Liping Xiang, Yuanfang Li, Minrui Ou, Ting Chi,
Zhenhua Liu, Suhong Yu, Yu Gao,
Jianzhong Chen, Jingwei Shao, Lee Jia. UP12, a novel ursolic acid derivative
with potential for targeting multiple signaling pathways in hepatocellular
carcinoma. Biochemical Pharmacology 93 (2015) 151–162. (IF = 5.009)
9. Yu
Li, Rong-jie Zeng, Jian-zhong Chena, Yan-bin Wu, Gui-xin Chou, Yu Gao, Jing-Wei Shao, Hua-zhu
Cai, Lee Jia. Pharmacokinetics and metabolism study of isoboldine, a major
bioactive component from Radix Linderae in male rats by UPLC–MS/MS. Journal
of Ethnopharmacology doi:10.1016/j.jep.2015.05.042. (IF = 2.998)
10. Rong-Jie Zeng, Yu Li, Jian-Zhong
Chen*, Gui-Xin Chou*, Yu Gao,
Jing-Wei Shao, Lee Jia, Sheng-Dong Wu, Shui-Sheng Wu. A novel UPLC-MS/MS method
for sensitive quantitation of boldine in plasma, a potential anti-inflammatory
agent: application to a pharmacokinetic study in rats. Biomedical Chromatography 29 (2015) 459–464 (IF = 1.723)
11. Haijun Chen, Xiaobin Zhou, Ailan
Wang, Yunquan Zheng, Yu Gao, Jia
Zhou*. Evolutions in Fragment-Based Drug Design: Deconstruction-Reconstruction
Approach. Drug Discovery Today 1 (2015) 105-113. (IF = 6.691)
12. Yu Gao,
Jingjing Xie, Haijun Chen, Songen Gu, Rongli Zhao, Jingwei Shao, Lee Jia*.
Nanotechnology-based intelligent drug design for cancer metastasis treatment. Biotechnology
Advances 32(2014)761-777. (IF = 9.015)
13. Yu Gao,
Jingwei Shao, Zhou Jiang, Songen Gu, Suhong Yu, Ke Zheng, Lee Jia*. Drug
enterohepatic circulation and disposition: constituents of systems pharmacokinetics.Drug
Discovery Today 19(2014)326-340. (IF = 6.691)
14. Haijun Chen1, Yu Gao1 (co-first author), Jianlei Wu, Yingyu
Chen, Buyuan Chen, Jianda Hub*, Jia Zhou*. Exploring Therapeutic Potentials of
Baicalin and Its Aglycone Baicalein for Hematological Malignancies. Cancer
Letters. 354(2014):5-11. (IF = 5.621)
15. Haijun Chen*, Guihua He, Cailong
Li, Longrong Dong, Xiaobo Xie, Yu Gao,
Jia Zhou*. Development of a Concise Synthetic Approach to Access Oroxin A. RSC
Advances. 4 (2014) 45151-45154. (IF = 3.840)
16. Jianzhong Chen, Jichuang Wang,
Jingwei Shao, Yu Gao, Jianguo
Xu, Suhong Yu, Zhenhua Liu, Lee Jia*. The unique pharmacological
characteristics of Mifepristone (RU486): from terminating pregnancy to
preventing cancer metastasis. Medicinal Research Reviews, 34 (2014)
979-1000 (IF = 8.431)
17. Haijun Chen*, Xiaobin Zhou, Yu Gao, Biyuan Zheng, Fengxiang
Tang, Jiandong Huang*. Recent progress in development of new sonosensitizers
for sonodynamic cancer therapy. Drug Discovery Today 19(2014)502-509.
(IF = 6.691)
18. Yusheng Lu, Ting Yu, Haiyan Liang,
Jichuang Wang, Jingjing Xie, Jingwei Shao, Yu
Gao, Suhong Yu, Shuming Chen, Lie Wang & Lee Jia. Nitric oxide
inhibits hetero-adhesion of cancer cells to endothelial cells: restraining
circulating tumor cells from initiating metastatic cascade. Sci
Rep 4(2014)4344. (IF = 5.578)
19. Jian-Zhong Chen, Ji-Chuang Wang, Yu Gao, Rong-Jie Zeng, Zhou
Jiang,Ye-Wei Zhu, Jing-Wei Shao, Lee Jia. A novel UPLC/MS/MS method for rapid
determination of metapristonein rat plasma, a new cancer metastasis chemopreventive
agentderived from mifepristone (RU486). Journal of Pharmaceutical and Biomedical
Analysis 95 (2014) 158–163. (IF = 2.979)
20. Yu Gao1, Yu Chen1, Xiufeng Ji1, Xinyu He, Qi Yin, Zhiwen
Zhang, Jianlin Shi, Yaping Li. Controlled intracellular release of doxorubicin
in multidrug resistant cancer cells by tuning the shell-pore sizes of mesoporous
silica nanoparticles. ACS Nano 5 (2011) 9788-9798. (IF = 12.881)
21. Yu Gao,
Lingli Chen, Zhiwen Zhang, Wangwen Gu, Yaping Li. Reversal of multidrug
resistance by reduction-sensitive linear cationic click polymer/iMDR1-pDNA
complex nanoparticles. Biomaterials 32 (2011) 1738-1747.
(IF = 8.557)
22. Qianjun He1, Yu
Gao1 (co-first
author), Lingxia Zhang, Zhiwen Zhang, Fang Gao, Xiufeng Ji, Yaping Li,
Jianlin Shi. A pH-responsive mesoporous silica nanoparticles-based multi-drug
delivery system for overcoming multi-drug resistance. Biomaterials 32
(2011) 7711-7720. (IF = 8.557)
23. Yu Gao1, Wangwen Gu1, Lingli Chen, Zhenghong Xu, Yaping Li. The role of
daidzein-loaded sterically stabilized solid lipid nanoparticles in therapy for
cardio-cerebrovascular diseases. Biomaterials 29 (2008)
4129-4136. (IF
= 8.557)
24. Jianan Shen1, Qianjun
He1, Yu Gao1(co-first author), Jianlin Shi,Yaping
Li. Mesoporous silica nanoparticles loading doxorubicin reverse multidrug
resistance: performance and mechanism. Nanoscale 3 (2011) 4314-4322. (IF = 7.394)
25. Yu Gao1, Rongfu Yang1,
Zhiwen Zhang, Lingli Chen, Zuyue Sun, Yaping Li. Solid lipid nanoparticles
reduce systemic toxicity of docetaxel: performance and mechanism in animal. Nanotoxicology 5 (2011)
636-649. (IF = 6.411)
26. Yu Gao1, Wangwen Gu1, Lingli
Chen, Zhenghong Xu, Yaping Li. A multifunctional nano device as non-viral
vector for gene delivery: in vitro characteristics and transfection. Journal of Controlled Release118 (2007) 381-388. (IF = 7.705)
27. Yu Gao, Lingli Chen, Zhiwen Zhang,
Wangwen Gu, Yaping Li. Linear cationic click polymer for gene delivery: synthesis,
biocompatibility, and in vitro transfection. Biomacromolecules 11 (2010) 3102-3111. (IF = 5.750)
28. Yu Gao,
Zhiwen Zhang, Lingli Chen, Wangwen Gu, Yaping Li. Synthesis of 6-N,N,N-trimethyltriazole
chitosan via “click chemistry” and evaluation for gene delivery. Biomacromolecules 10 (2009) 2175-2182. (IF = 5.750)
29. Yu Gao, Qi Yin, Lingli Chen, Zhiwen
Zhang, Yaping Li. Linear cationic click polymers/DNA nanoparticles: in vitro
structure-activity relationship and in vivo evaluation for gene delivery. Bioconjugate
Chemistry 22 (2011) 1153-1161. (IF = 4.513)
30. Yu Gao1, Lingli Chen1, Wangwen Gu, Yong Xi, Liping
Lin, Yaping Li. Targeted
nanoassembly loaded with docetaxel improves intracellular drug delivery and efficacy
in murine breast cancer model. Molecular Pharmaceutics 5 (2008) 1044-1054. (IF = 4.384)
31. Xiufeng Ji1, Yu Gao1 (co-first author), Lingli Chen, Zhiwen
Zhang, Yihui Deng, Yaping Li. Nanohybrid systems of non-ionic surfactant inserting
liposomes loading paclitaxel for reversal of multidrug resistance. International
Journal of Pharmaceutics 422 (2012) 390-397. (IF = 3.650)
32. Yu Gao1, Pengfei Xu1, Lingli Chen, Yaping Li. Prostaglandin E1 encapsulated into
lipid nanoparticles improves its anti-inflammatory effect with low side-effect.International Journal of Pharmaceutics 387 (2010) 263-271. (IF = 3.650)
33. Yu Gao,
Wangwen Gu, Lingli Chen, Yaping Li. Chitosan N-betainates/DNA self-assembly
nanoparticles for gene delivery: in vitro uptake and transfection efficiency. International Journal of
Pharmaceutics371 (2009) 156-162. (IF = 3.650)
34. Yu Gao,
Zhenghong Xu, Chen Shangwei, Wangwen Gu, Lingli Chen,Yaping Li. Arginine-chitosan/DNA
self-assemble nanoparticles for gene delivery: in vitro characteristics and
transfection efficiency. International Journal of Pharmaceutics359 (2008) 241-246. (IF = 3.650)
35. Yu Chen, Yu Gao, Hangrong
Chen, Deping Zeng, Yaping Li, Yuanyi Zheng, Faqi Li, Xiufeng Ji, Xia Wang, Feng
Chen, Qianjun He, Linlin Zhang, Jianlin Shi. Engineering inorganic nanoemulsions/nanoliposomes
by fluoride-silica chemistry for efficient delivery/co-delivery of hydrophobic agents.Advanced Functional Materials22 (2012) 1586-1597. (IF = 11.805)
36. Qianjun He, Yu
Gao, Lingxia Zhang, Wenbo Bu, Hangrong Chen, Yaping Li, Jianlin Shi. One-pot
self-assembly of mesoporous silica nanoparticle-based pH-responsive anti-cancer
nano drug delivery system. Journal of Materials Chemistry 21 (2011)
15190-15192. (IF = 7.443)
37. Qi Yin, Yu Gao,
Zhiweng Zhang, Pengcheng Zhang, Yaping Li. Bioreducible poly (β-amino
esters)/shRNA complex nanoparticles for efficient RNA delivery. Journal of Controlled Release 151
(2011) 35-44. (IF = 7.705)
38. Yongxin Yang, Yu Gao, Lingli Chen, Yongzhuo Huang, Yaping Li. Downregulation
of survivin expression and enhanced chemosensitivity of MCF-7 cells to
adriamycin by PDMAE/survivin shRNA complex nanoparticles. International
Journal of Pharmaceutics 405 (2011)188-195. (IF = 3.650)
39. Huihui Bu, Yu Gao, Yaping Li. Overcoming multidrug resistance
(MDR) in cancer by nanotechnology. Sci.ChinaSer. B-Chem. 53 (2010)
2226-2232. (IF
= 0)
40. Qianjun
He, Zhiwen Zhang, Yu Gao,
Jianlin Shi, Yaping Li. Intracellular localization and cytotoxicity of
spherical mesoporous silica nano- and microparticles. Small 5（2009）2722-2729. (IF = 8.368)
41. Wangwen
Gu, Zhenghong Xu, Yu Gao, Lingli Chen, Yaping Li. Transferrin-mediated PEGylated nanoparticles
for delivery of DNA/PLL complexes. Nanotechnology 17 (2006) 4148-4155. (IF = 3.821)
42. Zhenghong
Xu, Lingli Chen, Wangwen Gu, Yu Gao, Liping Lin, Zhiwen Zhang,
Yong Xi, Yaping Li. The
performance of docetaxel-loaded solid lipid nanoparticles targeted to
hepatocellular carcinoma. Biomaterials 30 (2009) 226-232. (IF = 8.557)
43. Yongxin
Yang, Zhenghong Xu, Jingui Jiang, Yu Gao, Wangwen Gu, Yaping Li. Poly(imidazole/DMAEA)phosphazene/DNA
self- assembled nanoparticles for gene delivery: synthesis and in vitro
transfection.Journal of Controlled Release 127
(2008) 273-279. (IF = 7.705)
44. Zhenghong
Xu, Wangwen Gu, Lingli Chen, Yu Gao, Zhiwen Zhang, Yaping Li. A smart nanoassembly
consisting of acid-labile vinyl ether PEG-DOPE and protamine
for gene delivery: preparation and in vitro transfection. Biomacromolecules9 (2008) 3119-3126.
(IF = 5.750)
45. Yongxin Yang, Zhenghong Xu, Shangwei Chen, Yu Gao,
Wangwen Gu, Lingli Chen, Yuanying Pei, Yaping Li. Histidylated cationic
polyorganophosphazene/DNA self-assembled nanoparticles for gene delivery.[My paper] International Journal of
Pharmaceutics353 (2008) 277-282. (IF =
3.650)
46. Pengcheng Zhang, Lingli Chen, Wangwen Gu, Zhenghong Xu, Yu
Gao, Yaping Li. In vitro and in vivo evaluation of donepezil-sustained
release microparticles for the treatment of Alzheimer’s disease. Biomaterial28 (2007) 1882-1888. (IF = 8.557)
获奖情况
☆ 2015年福州大学化学学院本科生优秀毕业论文奖 (指导老师)
☆ 2015年福建省药学会药剂专业委员会学术年会优秀论文三等奖 (指导老师)
☆ 2014年福建省药学会药剂专业委员会学术年会优秀论文三等奖 (指导老师)
☆ 2014年福州大学本科生优秀毕业论文奖 (指导老师)
☆ 2013年福建省药学会药剂专业委员会学术年会优秀论文一等奖 (指导老师)
☆ 2013年上海药学科技一等奖（第五完成人）
☆ 2011年中国科学院百篇优秀博士论文
☆ 2010年中国科学院院长奖优秀奖
☆ 中科院2009-2010学年“三好学生标兵”
☆ 2010年中国微米纳米技术学会纳米科学技术分会第二届年会优秀墙报奖
☆ 2010年上海市药学会“现代杯”药剂学研究生论文报告会二等奖
☆ 2010年上海药物研究所学术年会研究生学术报告三等奖
☆ 2009年上海药学科技一等奖（第三完成人）
☆ 2009年上海药物研究所优秀论文二等奖
☆ 中科院2008-2009学年“三好学生”
☆ 2008年上海药物所优秀论文奖一等奖
☆ 2008年第十一届华东地区药剂学术会议论文二等奖
☆ 2007年上海药物所优秀论文奖
☆ 2007年度中国科学院地奥奖学金二等奖
☆ 中科院2006-2007学年“三好学生”
☆ 2005年福州大学“优秀毕业生”
指导本科生科研项目
1、 基于PAMAM树状大分子的肿瘤靶向纳米药物的构建和体外抗肿瘤作用研究，国家基础科学人才培养基金《能力提高》项目（J1103303, J2013-026），2013.06-2015.05
2、 米非司酮壳聚糖微球的制备及体内药动学研究，福建省“大学生创新训练计划”项目（201410386055），2014.05-2015.05
3、 适配体修饰介孔二氧化硅纳米载体的构建及其抗肿瘤转移作用研究，第二十一期本科生科研训练计划项目（21035），2015.06-2016.05
4、 叶酸过表达肿瘤选择性靶向抗癌纳米药物的构建及其体外抗肿瘤活性研究，第二十一期本科生科研训练计划项目（21044），2015.06-2016.05
学术兼职
☆ 美国药学会(AAPS)会员
☆ 福建省药学会药剂专业委员会委员
☆ 中国毒理学会会员
☆ 中国生物物理学会自由基生物学与自由基医学专业委员会青年委员
☆ 福建省药理学会会员
