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美国药学学会-福州大学分会
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邵敬伟——研究所副所长;化工制药系主任
发布日期:2012-11-27    浏览次数:

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    邵敬伟,博士,教授,硕士生导师。2004年人才引进到福州大学化学化工学院制药工程系从事教学科研工作,主要研究方向为抗癌药物药理学及细胞凋亡信号通路等分子药理学研究,积累了较为丰富的经验。近几年致力于肿瘤循环细胞(CTC)及药物对肿瘤的增殖抑制、抗肿瘤细胞粘附及肿瘤转移等方向的研究工作。于2011-2012年公派留学到美国阿肯色州医科大学Winthrop P. Rochefelle癌症研究所进行课题交流研究,主要开展靶向抗癌药物及纳米医学等领域的研究。现任美国药学会(AAPS)会员并兼任美国药学会药物设计和开发委员会委员,福建省药理学会会员并兼任理事。近年来作为技术骨干成员参与福州大学功能材料研究所新型抗癌药物———“福大赛因” (photocyanine) 的临床前试验研究并负责完成该课题组药学活性平台的建设。主持(或参加)国家基金3项,主持(或参加)省部级项目10余项,作为技术骨干参与国家“重大新药创制”科技重大专项“十二五”实施计划项目及福建省科技厅重大项目等科研课题。申请国家发明专利10项,已获得专利授权3项。累计在国内外期刊发表论文50余篇,自2011年至今共发表与肿瘤防治研发相关的药理、药代及生物纳米医学等SCI论文16篇,其中以第一作者(或通讯作者身份发表SCI论文12 篇。文章累计总影响因子75.485,单篇最高影响因子10.927 。2012年底入选闽港合作博士后人才培养计划。(更新至2013年9月) 


代表性论文:

2014年

 

[1] Wang J, Chen J, Wan L, Shao J*, Lu Y, Zhu Y, Ou M, Yu S, Chen H, Jia L*. Synthesis, spectral characterization, and in vitro cellular activities of metapristone, a potential cancer metastatic chemopreventive agent derived from mifepristone (RU486). AAPS J., 16(2), 289-298, 2014.

[2] Lu Y, Yu T, Liang H, Wang J, Xie J, Shao J*, Gao Y, Yu S, Chen S, Wang L, Jia L*. Nitric oxide inhibits hetero-adhesion of cancer cells to endothelial cells: restraining circulating tumor cells from initial metastatic cascade. Sci. Reports, 4, 4344, 2014.

[3] Jiang Z#, Shao J#, Yang T, Wang J, Jia L*. Pharmaceutical development, composition and quantitative analysis of phthalocyanine as the photosensitizer for cancer photodynamic therapy. J. Pharm. Biomed. Anal., 87:98-104, 2014.

[4] Chen J, Wang J, Shao J, Gao Y, Xu J, Yu S, Liu Z, Jia L*. The Unique Pharmacological Characteristics of Mifepristone: from Terminating Pregnancy to Preventing Cancer Metastasis. Med. Res. Rev., DOI: 10.1002/med.21311, 2014.

2013年

[1] Shao J, Jia L*. Potential serious interactions between nutraceutical ginseng and warfarin in patients with ischemic stroke. Trends Pharmcol. Sci., 34(2), 85-86, 2013.

[2] Shao J, Robert J, Ekaterina I, Kim J, Nathan K, Jessica W, Thikra M, Alexandru B, Dmitry A, Zharov VP*. Photothermal nanodrugs: potential of TNF-gold nanospheres for cancer theranostics. Sci. Reports, 3, 1293, 2013.

[3] Shao J, Dai Y, Zhao W, Xie J, Jia L*. Intracellular distribution and mechanisms of actions of photosensitizer Zinc (II)-phthalocyanine solubilized in Cremophor EL against human hepatocellular carcinoma HepG2 cells. Cancer Lett., 330, 49-56, 2013.

[4] Xie J#, Shao J#, Lu Y, Chen J, Wang J, Yu S, Jia L*. Separation of ginseng active ingredients and their roles in cancer metastasis supplementary therapy. Curr. Drug Metab., 14, 614-621, 2013.

[5] Gao Y#, Shao J#, Jiang Z, Chen J, Gu S, Yu S, Zheng K, Jia L*. Drug enterohepatic circulation and disposition: constituents of systems pharmacokinetics. Drug Discov. Today, DOI:10.1016/j.drudis.2013.11.020., 2013.

[6] Jiang Z#, Shao J#, Chen M, Wang J, Jia L*. A novel SPE-HPLC method for simultaneous determination of selected sulfonated phthalocyanine zinc complexes in mouse plasma following cassette dosing. Analyst, 138(15): 4385-92, 2013.

[7] Jia L*, Lu Y, Shao J, Liang X, Xu Y*. Nanoproteomics: a new spin from emerging links  between nanotechnology and proteomics. Trends Biotech., 31(2), 99-107, 2013.

[8] Dong Y, Pang H, Yang HB, Guo C, Shao J, Chi Y, Li CM*, Yu T*. Carbon-based dots co-doped with nitrogen and sulfur for high quantum yield and excitation-independent emission. Angew. Chem. Int. Ed. Engl., 52(30):7800-7804, 2013.

[9] Gao Y, Xie J, Chen H, Gu S, Zhao R, Shao J, Jia L*. Nanotechnology-based intelligent drug design for cancer metastasis treatment. Biotechnol. Adv., DOI:10.1016/j.biotechadv.2013.10.013, 2013.

2012年及以前

[1] Shao J, Xue J, Dai Y, Liu H, Chen N*, Jia L*, Huang J. Inhibition of human hepatocellular carcinoma HepG2 by phthalocyanine photosensitiser PHOTOCYANINE: ROS production, apoptosis, cell cycle arrest. Eur. J. Cancer, 48(13), 2086-2096, 2012.

[2] Shao J, Zhang F, Bai Z, Wang C, Yuan Y, Wang W*. Synthesis and antitumor activity of emodin quaternary ammonium salt derivatives. Eur. J. Med. Chem., 56, 308-319, 2012.

[3] Shao J, Lin M, Li Y, Li X, Liu J, Liang J, Yao H*. In vivo blood glucose quantification using raman spectroscopy. PLoS One, 7(10), e48127, 2012.

[4] Shao J, Yao H*, Meng L, Li Y, Lin M, Li X, Liu J, Liang J. Raman spectroscopy of circulating single red blood cells in microvessels in vivo. Vib. Spectrosc., 63, 367-370, 2012.

[5] Wang W, Bai Z, Zhang F, Wang C, Yuan Y, Shao J*. Synthesis and biological activity evaluation of emodin quaternary ammonium salt derivatives as potential anticancer agents. Eur. J. Med. Chem., 56, 320-331, 2012.

[6] Dong Y, Shao J, Chen C, Li H, Wang R, Chi Y*, Lin X, Chen G. Blue luminescent graphene quantum dots and graphene oxide prepared by tuning the carbonization degree of citric acid. Carbon, 50(12), 4738-4743, 2012.

[7] Zhang F, Xue J, Shao J, Jia L*. Compilation of 222 drugs’ plasma protein binding data and guidance for study designs. Drug Discov. Today, 17(9-10), 475-485, 2012.

[8] Dong Y, Wang R, Li H, Shao J, Chi Y*, Lin X, Chen G. Polyamine-functionalized carbon quantum dots for chemical sensing. Carbon, 50(8), 2810-2815, 2012.

[9] Shao J*, Dai Y, Xue J, Wang J, Lin F, Guo Y. In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives. Eur. J. Med. Chem., 46(7), 2652-2661, 2011.

 会议摘要:

[1] Shao J*, Li Y, Wang J, Lin L, Yu X, Xiang X, Jia L. Combination therapy with USW-006 and glycolytic inhibitors in cancer cells. Poster presentation at the 2013 AAPS@ China Symposium, the Chinese University of Hong Kong, August 17-18, 2013.

[2] Xie J, Gao Y, Zhao R, Shao J, Gu S, Lu Y, Zhu Y, Pang Y, Xiang Li, Jia L*. Functionalization of nanomaterials G6 PAMAM dendrimers with anti-Sialyl Lewis X antibody and their ability to capture and down-regulate cancer cells. Poster presentation at the 2013 AAPS Annual Meeting and Exposition. Poster M1061. San Antonio, USA, November 10-14, 2013.

[3] Chen J, Wang J, Xu J, Shao J, Jia L*. A novel UPLC/MS/MS method and its application to pharmacokinetic determination of metapristone: A novel cancer metastasis chemopreventive agent derived from RU486—difference between genders. Poster presentation at the 2013 AAPS Annual Meeting and Exposition. Poster T3182. San Antonio, USA, November 10-14, 2013.

[4] Xie J, Zhao R, Gu S, Shao J, Lu Y, Wang J, Jia L*. Surface-functionalizing modification of nanomaterial dendrimer PAMAM with anti-epithelial cell adhesion molecule antibody for its binding to colon cancer cells HT29. National Biotechnology Conference, San Diego, USA, November 10-14, 2013.

[5] Lu Y, Yu T, Liang H, Xie J, Wang J, Xu J, Shao J, Jia L*. S-nitrosocaptopril interferes hetero-adhesion between human colon cancer cells HT-29 and vascular endothelial cells.  AAPS annual meeting; AM-13-0574, San Antonio, UAS, November 10-14, 2013.

[6] Wang J, Wan L, Lu Y, Zhu Y, Xie J, Yu T, Shao J, Jia L*. Synthesis, characterization and anti-adhesion effect of metapristone, a novel cancer metastasis chemopreventive agent derived from RU486 (Mifepristone). Poster presentation at the 2013 AAPS Annual Meeting and Exposition. Poster T3014. San Antonio, USA, November 10-14, 2013.

[7] Wang J, Shao J, Xie J, Zhang F, Lu Y, Jia L*. Design, synthesis and anticancer activity of a series of ursolic acid derivatives conjugated to folate: targeting folate receptors on cancer cells. Poster presentation at the 2012 AAPS Annual Meeting and Exposition, Poster T3023. Chicago, USA, October 14-17, 2012.

[8] Shao J, Dai Y, Xue J, Jia L*. Anticancer activity and mechanism of photosensitizer ZnPc on human hepatocellular carcinoma cell HepG2. Poster presentation at the 2011 AAPS Annual Meeting and Exposition, AAPS J, 13(S2). Poster W4057. Washington D.C., USA, October 23-27, 2011.

[9] Shao J, Du H, Bai Z, Xie J, Cheng X, Jia L*. Effects of fermentation conditions on the growth of Cordyceps kyushuensis in submerged culture and its antioxidative and anticancer activity in vitro. Poster presentation at the 2011 AAPS Annual Meeting and Exposition, AAPS J, 13(S2). Poster T2015. Washington D.C., USA, October 23-27, 2011.

[10] Xue J, Shao J, Dai Y, Liu H, Chen N, Huang J, Jia L*. Overview of global development of photodynamic therapy for cancer and China’s first generation of photosensitizer ZnPcS2P2 in clinical trials. 17th International Biophysics Congress (IUPAB), Beijing. October 30- November 3, 2011.

[11] Xue J, Fang Y, Zhang F, Shao J, Jia L*, Liu H, Chen N, Huang J. Preparation and in vitro photodynamic activities of a novel mono(8-quinolinoxy) phthalocyanato zinc(II). Poster presentation at the 2011 AAPS Annual Meeting and Exposition, AAPS J, 13(S2). Poster W4078. Washington D.C., USA, October 23-27, 2011. 

 

主持科研项目:
 

1. 预防肝癌复发转移:熊果酸对肝癌细胞粘附于血管内膜的干预作用及分子机制研究 福建省自然科学基金面上项目(2014J01364,2014-2016)

2. 雷公藤内酯醇控释纳米涂膜剂治疗皮肤鳞癌及其作用机制的研究 国家卫计委共建科学研究基金项目 (WKJ-FJ-15,2013-2016)

3. 熊果酸抗肿瘤转移作用机制研究 中国博士后科学基金特别资助项目(2013T60638,2013—2015)  
 

4. 叶酸靶向的熊果酸衍生物抗癌活性比较研究及其作用机制探讨。国家自然科学基金青年基金项目(81201709,2013—2015)

5.  熊果酸哌嗪衍生物-叶酸复合物靶向抗癌活性及机制研究。中国博士后科学基金面上项目(2012M511441,2012—2014)

6.  低毒性纳米荧光标记物研究及在肿瘤细胞成像和检测。福州大学博士后启动基金(600565,2011—2013)

7.  熊果酸及其衍生物对人肿瘤细胞凋亡诱导作用及机理研究。福建省教育厅科技项目A类(JA08004,2008-2010)。

8.  “福大赛因”对人肿瘤细胞凋亡诱导作用及机理研究。福州大学科技发展基金(2009-XQ-12,2009-2011)。

9.  熊果酸及其衍生物对人肿瘤细胞凋亡诱导作用及机理研究。福建省科技厅青年科技人才创新项目(2007F0347,2007-2009)。

10.  转录与分泌水平双重调控突变胰岛素原表达的研究。福建省教育厅科技项目B类(JB05020,2005-2007)。

11.  用人PXR报告基因试验研究抗肿瘤药物的CYP3A4调节机制。福州大学校人才基金项目(HX2005-32,2005-2008)


参与科研项目:

 

973计划: 项目编号:2015CB931800; 项目名称:肺癌在体分子分型的新型纳米分子成像探针基础研究; 课题组: 基于在体分子分型的肺癌个体化治疗及评价; 项目起止时间:2015年1月-2019年8月;  


 

指导本科生科研项目:

1.  RGD修饰的熊果酸纳米药物制备及其对肿瘤细胞的靶向结合作用,2013-2015,国家人才基金(J2013—023)

2.  VEGF靶向载药纳米胶束的制备及其性能研究,2014-2015, 国家大学生创新训练计划(201410386011)

3.  熊果酸对乳腺癌细胞4T-1粘附与迁移的影响及机制研究, 2014-2015,福建省大学生创新训练计划(201410386056)

4.  熊果酸RGD聚合物胶束肿瘤靶向给药系统的表征及体外药效评价, 2013-2014, 福建省大学生创新训练计划(201310386068)


获授权的专利:

1.  一种具有抗肿瘤活性的熊果酸哌嗪类衍生物及其制备方法 - 201010240154.X

2.  具有抗癌活性的羟基全保护的双癸基季铵盐及其制备方法 - 201010295815.9

3.  具有抗癌活性的β-羟基保护的双癸基季铵盐及制备方法 - 201010295813.X

4.  一种具有抗癌活性的单羟基大黄素二正辛基季铵盐 - 201110135298.3





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